I just spent a great New Year's Eve in Houston with some very old and dear friends. This trip came on the heels of my trip to NY to spend Christmas with my wife and daughter. It would have been very easy to not take the 3 1/2 hour drive, to stay at home for New Year's, but I chose to say "yes."
All too often we choose to say "no" because it's easy and expeditious. We make excuses in defense of our "no" - it costs too much money, I don't have enough time, I'll do it later, etc., etc... This is a very sad way to live life - turning down passions, dreams, love, excitement, happiness, and all the other good things that life has to offer, all because it's easier to say "no."
Say "yes" to your life. Start doing the things that you want to do, make a living the way you want to make it, and embrace your passions. Quit saying "no."